S
SnAkE_OnE
no me gusta , primero tenes la sensación de ahogarte
Sensacion de ahogarte o morirte? vos que elegis?
no me gusta , primero tenes la sensación de ahogarte
Sensacion de ahogarte o morirte? vos que elegis?
No es lo que pasa acaso cuando TODO ser humano está dentro de la madre??? Claro, hasta que nace... Tan antinatural no me parecería...Afirmar que el cuerpo humano no necesita preparación especial para respirar el un líquido me parece ingenuo. Improbable.
Pero eso es lo lindo de la ciencia. Teorías extraordinarias necesitan pruebas extraordinarias verificables.
Hay un indicador que es la presión arterial de O2 o de CO2, que estudia la gasometría arterial. Tiene distintos valores en sangre venoso o sangre arterial se mide en mmHG. No todo es plasma-El organismo es gasero sólo hasta los pulmones, justamente la función de éstos es diluir el oxígeno en la sangre. Lo mismo en sentido inverso, el anhídrido carbónico que vuelve en la sangre es convertido a gas y exhalado.
Afirmar que el cuerpo humano no necesita preparación especial para respirar el un líquido me parece ingenuo. Improbable.
Pero eso es lo lindo de la ciencia. Teorías extraordinarias necesitan pruebas extraordinarias verificables.
Medical treatment[edit]
Computer-generated model of perflubron and gentamicin molecules in liquid suspension for pulmonary administration
The most promising area for the use of liquid ventilation is in the field of pediatric medicine.[25][26][27] The first medical use of liquid breathing was treatment of premature babies[28][29][30][31] and adults with acute respiratory distress syndrome (ARDS) in the 1990s. Liquid breathing was used in clinical trials after the development by Alliance Pharmaceuticals of the fluorochemical perfluorooctyl bromide, or perflubron for short. Current methods of positive-pressure ventilation can contribute to the development of lung disease in pre-term neonates, leading to diseases such as bronchopulmonary dysplasia. Liquid ventilation removes many of the high pressure gradients responsible for this damage. Furthermore, perfluorocarbons have been demonstrated to reduce lung inflammation,[32][33][34] improve ventilation-perfusion mismatch and to provide a novel route for the pulmonary administration of drugs.[35][36][37]
In order to explore drug delivery techniques that would be useful for both partial and total liquid ventilation, more recent studies have focused on PFC drug delivery using a nanocrystal suspension. The first image is a computer model of a PFC liquid (perflubron) combined with gentamicin molecules.
The second image shows experimental results comparing both plasma and tissue levels of gentamicin after an intratracheal (IT) and intravenous (IV) dose of 5 mg/kg in a newborn lamb during gas ventilation. Note that the plasma levels of the IV dose greatly exceed the levels of the IT dose over the 4 hour study period; whereas, the lung tissue levels of gentamicin when delivered by an intratracheal (IT) suspension, uniformly exceed the intravenous (IV) delivery approach after 4 hours. Thus, the IT approach allows more effective delivery of the drug to the target organ while maintaining a safer level systemically. Both images represent the in-vivo time course over 4 hours. Numerous studies have now demonstrated the effectiveness of PFC liquids as a delivery vehicle to the lungs.[38][39][40][41][42][43][44][45][46][47]
Comparison of IT and IV administration of gentamicin.
Clinical trials with premature infants, children and adults were conducted. Since the safety of the procedure and the effectiveness were apparent from an early stage, the US Food and Drug Administration (FDA) gave the product "fast track" status (meaning an accelerated review of the product, designed to get it to the public as quickly as is safely possible) due to its life-saving potential. Clinical trials showed that using perflubron with ordinary ventilators improved outcomes as much as usinghigh frequency oscillating ventilation (HFOV). But because perflubron was not better than HFOV, the FDA did not approve perflubron, and Alliance is no longer pursuing the partial liquid ventilation application. Whether perflubron would improve outcomes when used with HFOV or has fewer long-term consequences than HFOV remains an open question.
In 1996 Mike Darwin and Dr. Steven B. Harris proposed using cold liquid ventilation with perfluorocarbon to quickly lower the body temperature of victims of cardiac arrest and other brain trauma to allow the brain to better recover.[48] The technology came to be called gas/liquid ventilation (GLV), and was shown able to achieve a cooling rate of 0.5 °C per minute in large animals.[49] It has not yet been tried in humans.
Most recently, hypothermic brain protection has been associated with rapid brain cooling. In this regard, a new therapeutic approach is the use of intranasal perfluorochemical spray for preferential brain cooling.[50] The nasopharyngeal (NP) approach is unique for brain cooling due to anatomic proximity to the cerebral circulation and arteries. Based on preclinical studies in adult sheep, it was shown that independent of region, brain cooling was faster during NP-perfluorochemical versus conventional whole body cooling with cooling blankets. To date, there have been four human studies including a completed randomized intra-arrest study (200 patients).[51][52] Results clearly demonstrated that prehospital intra-arrest transnasal cooling is safe, feasible and is associated with an improvement in cooling time.
Y el peso de llenar la cabina de liquido? y el peso de la estructura circundante reforzada? Y la Posición del CG cdo no es normal semejante peso adelante? Y las alas que se van quedando sin combustible y tienen que bancarse una bañadera ahi adelante? Y la eyección? como sacas todo eso de golpe cuando la salvacion depende de un segundo?....Reforzar tren, alas, zona circundante a cabina = Peso, mas peso y mas peso
Se banca las g......pero lleva una linda inercia esa masa de liquido a 9G......y como le va con los cambios repentinos de presión (tipo una explosion cercana)
Y el peso de llenar la cabina de liquido? y el peso de la estructura circundante reforzada? Y la Posición del CG cdo no es normal semejante peso adelante? Y las alas que se van quedando sin combustible y tienen que bancarse una bañadera ahi adelante? Y la eyección? como sacas todo eso de golpe cuando la salvacion depende de un segundo?....Reforzar tren, alas, zona circundante a cabina = Peso, mas peso y mas peso
Se banca las g......pero lleva una linda inercia esa masa de liquido a 9G......y como le va con los cambios repentinos de presión (tipo una explosion cercana)